Atypical femoral fractures due to the use of bisphosphonates: epidemiologic study in a tertiary hospital / Fraturas atípicas de fêmur por uso de bifosfonatos: estudo epidemiológico em um hospital terciário

ABSTRACT Objective: Show the relationship between atypical femoral fractures and prolonged use of bisphosphonates and analyze the limit of its beneficial use. Methods: Retrospective cohort study (level of evidence 2B). From Atypical fracture cases, patients who used bisphosphonates were selected and the time period of their use was analyzed. Additionally, the variables sex, age, and the side most affected were studied. Results: Nine atypical femur fractures were found, all associated with the use of bisphosphonates. The average period of use of this medication was nine years (minimum of three years; maximum of 14 years). The patients' mean age was of 78 years (69-88 years) and all were women, with the right member being the most affected. Conclusion: The use of bisphosphonates to prevent osteoporotic fractures has been increasingly frequent and, when used for a prolonged period, it has been related to atypical fractures. Further scientific studies on doses, maximum periods of treatment, and risk-benefit in the indication of these medications are needed to assist in therapeutic management for each case. Level of Evidence II, Retrospective Study.

RESUMO Objetivo: Demonstrar relação entre as fraturas atípicas de fêmur e o uso prolongado de bifosfonatos, descrever sua incidência e analisar até qual momento o seu uso é benéfico. Métodos: Estudo de coorte retrospectivo (nível de evidência 2B). Análise de 151 prontuários de pacientes com diagnóstico de fratura de fêmur em um hospital terciário, no período de janeiro de 2013 a dezembro de 2018. Foram selecionados os casos de fraturas atípicas e, dentre esses, os que faziam uso de bifosfonatos e o tempo de utilização. Ademais, foram estudadas as variáveis sexo, idade e lado mais acometido. Resultados: Constatadas 9 fraturas atípicas de fêmur, todas associadas ao uso de bifosfonatos. O período médio de uso dessa medicação foi de 9 anos (mínimo - 3 anos; máximo - 14 anos). A idade média dos pacientes foi de 78 anos (69-88 anos) e ocorrência unicamente em mulheres, tendo como membro mais acometido o direito. Conclusão: O uso dos bifosfonatos na prevenção de fraturas osteoporóticas tem sido cada vez mais frequente e relacionado às fraturas atípicas, quando empregado por tempo prolongado. A coleta de mais informações científicas que estudem doses, períodos máximos de tratamento e risco-benefício na indicação dessas medicações é essencial para auxiliar no manejo terapêutico apropriado para cada caso. Nível de Evidência II, Estudo Retrospectivo .

Tratamiento de las fracturas trocántero-subtrocantéricas asociadas a coxartrosis ipsilateral en pacientes mayores de 65 años / Treatment of trochanteric and subtrochanteric fractures associated to ipsilateral coxarthrosis in patients older than 65 years old / Tratamento de fraturas trocantéricas-subtrocantéricas associadas a coxartrose ipsilateral em pacientes com mais de 65 anos

Resumen: Introducción: las fracturas de cadera y la coxartrosis son patologías con alta incidencia en la población anciana. A pesar de esto es una observación clínica frecuente que no se presenten asociadas. No existe consenso de cuál es la mejor opción terapéutica para esta asociación. El objetivo del estudio es actualizar el conocimiento acerca del tratamiento de fracturas trocántero-subtrocantéricas asociadas a coxartrosis ipsilateral en pacientes mayores de 65 años. Materiales y métodos: se realizó una búsqueda sistematizada a través de los buscadores electrónicos PubMed y Ovid. La búsqueda alcanzó un total de 2,499 artículos, de acuerdo a los criterios de inclusión y exclusión se seleccionaron 12 trabajos para realizar nuestra revisión bibliográfica. Resultado: la mayoría de los trabajos analizados son estudios tipo serie de casos retrospectivos. Se realizaron tres subgrupos según tipo de tratamiento para analizar los resultados. Discusión: la asociación entre fracturas de fémur proximal y coxartrosis ipsilateral es poco frecuente. Dentro de este grupo de fracturas las de tipo trocantérico son las que muestran con mayor frecuencia esta asociación. Se plantean dos opciones terapéuticas para resolver esta asociación: tratar la fractura y la patología articular en un mismo acto quirúrgico mediante una artroplastia, o tratar primero la fractura mediante osteosíntesis y en una segunda cirugía la patología articular. El tratamiento mediante artroplastia disminuye el tiempo para la deambulación postoperatoria evitando así complicaciones médicas relacionadas a la enfermedad fracturaria, obteniendo mejores resultados funcionales a corto plazo. La osteosíntesis requiere un menor tiempo quirúrgico y una perdida sanguínea menor, siendo un procedimiento menos demandante técnicamente. La tasa de mortalidad no depende de la opción terapéutica, pero sí de la presencia de 3 o más comorbilidades y edad mayor a 80 años. Resulta importante conocer el tratamiento más adecuado para esta asociación de patologías, ello contribuiría a disminuir los efectos de la enfermedad fracturaria sobre este grupo de pacientes vulnerables. Conclusión: no existe la suficiente evidencia científica para afirmar que una opción terapéutica sea superior a la otra en estos pacientes.

Summary: Introduction: hip fractures and hip joint arthrosis are highly prevalent conditions among older adults. However, according to clinical examination, they are seldom seen together and today there is no general consensus on the best therapy for these associated conditions. The study aims to update existing knowledge on the treatment of trochanteric and subtrochanteric fractures that are associated to ipsilateral coxarthrosis in patients older than 65 years old. Method: we conducted a systematized search on Pubmed and Ovid including 2,499 articles and selected 12 studies to perform our bibliographic review based on inclusion and exclusion criteria. Result: most studies analysed are series of retrospective cases. Cases were classified them into three subgroups to analyse results. Discussion: the association between proximal femur fractures and ipsilateral coxarthrosis is rather unusual. When seen, trochanteric fractures are the most frequent ones. There are two therapeutic options to treat this condition: treating the fracture and the articulation in the same surgery, by means of an arthroplasty, or treating the fracture first with osteosynthesis and operating afterwards to treat the articulation condition. Arthroplasty reduces the time of postoperative ambulation and thus avoids medical complications in connection with the fracture disease, what results in better functional outcome in the short term. Osteosynthesis requires a shorter surgery and implies smaller blood loss, what makes it less technically demanding as a procedure. The mortality rate does not depend on the therapy chosen, but on the presence of three or more comorbilities, or the patient being older than 80 years old. It is important to define what the most appropriate treatment is for these associated conditions, what would contribute to reducing the effects of the fracture on this group of vulnerable patients. Conclusion: there is no sufficient scientific evidence to state whether one therapy is better than the other one in these patients.

Resumo: Introdução: as fraturas de quadril e coxartrose são patologias com alta incidência na população idosa. Apesar disso, é frequente a observação clínica de que não estão associados. Não há consenso sobre qual a melhor opção terapêutica para essa associação. O objetivo deste estudo é atualizar o conhecimento sobre o tratamento das fraturas trocantéricas-subtrocantéricas associadas à coxartrose ipsilateral em pacientes com mais de 65 anos. Materiais e métodos: foi realizada uma busca sistemática nas bases PubMed e Ovid. Foram encontrados 2.499 artigos; após aplicação dos critérios de inclusão e exclusão, foram selecionados 12 artigos para realização de nossa revisão bibliográfica. Resultado: a maioria dos estudos analisados são séries de casos retrospectivos. Para análise dos resultados, foram divididos em três subgrupos de acordo com o tipo de tratamento. Discussão: a associação entre fratura de fêmur proximal e coxartrose ipsilateral é rara. Dentro desse grupo de fraturas, as do tipo trocantérica são as que mais frequentemente apresentam essa associação. Duas opções terapêuticas são propostas para resolver essa associação: tratar a fratura e a patologia articular no mesmo ato cirúrgico por meio de uma artroplastia, ou tratar a fratura primeiro por osteossíntese e em uma segunda cirurgia a patologia articular. O tratamento por artroplastia reduz o tempo de deambulação pós-operatória, evitando complicações médicas relacionadas à doença da fratura, obtendo melhores resultados funcionais em curto prazo. A osteossíntese requer menos tempo cirúrgico e menos perda sanguínea, sendo um procedimento menos exigente tecnicamente. A taxa de mortalidade não depende da opção terapêutica, mas sim da presença de 3 ou mais comorbidades e idade superior a 80 anos. É importante identificar o tratamento mais adequado para esta associação de patologias, o que ajudaria a reduzir os efeitos da patologia da fratura neste grupo de pacientes vulneráveis. Conclusão: não há evidências científicas suficientes para afirmar que uma opção terapêutica seja superior a outra nestes pacientes.

Clinical effectiveness of less invasive intramedullary nail fixation combined with titanium cable cerclage for subtrochanteric fractures / 北京大学学报(医学版)

OBJECTIVE@#To evaluate the surgical technique and clinical effect of less invasive intrame-dullary nail fixation combined with titanium cable cerclage in the treatment of subtrochanteric fractures.@*METHODS@#A retrospective study was performed in 46 cases of subtrochanteric fractures in Peking University People's Hospital from January 2015 to December 2017. Among them, there were 14 males and 32 females, with an average age of (77.83±10.66) years (44-92 years); 17 cases on the left side and 29 cases on the right side. The causes of injury included crash from a height, traffic accident and accidental fall. According to Seinsheimer classification, there were 26 cases of type Ⅱ, 11 cases of type Ⅲ, 9 cases of type Ⅳ, and these cases were all closed injury. After admission, these patients underwent continuous tibial tuberosity bone traction to maintain the length and force line of the lower extremity, so as to reduce the difficulty of intraoperative fracture reduction. Anticoagulant therapy was given before operation to reduce perioperative thrombotic complications. All the patients were treated with less invasive intramedullary nail fixation combined with titanium cable cerclage. Operation time, blood loss during surgery, time of fracture healing were recorded, Harris and Sanders scoring system were used to assess hip function after operation at each follow-up time point.@*RESULTS@#All the included patients underwent surgery successfully. Average operative time and intraoperative blood loss of these patients were (131.09 ± 20.06) min and (191.96±111.03) mL, respectively. All the patients were followed up satisfactorily, with an average follow-up time of 28 months. The fractures received bone healing within 3-6 months, average hospital stay was (10.61±2.85) days. The Sanders score was excellent in 3 cases, good in 37 cases and common in 6 cases, with an excellent and good rate of 86.96%. The Harris score was excellent in 6 cases, good in 36 cases, with an excellent and good rate of 91.30%. There were no cases of wound infection, loss of reduction, nonunion of fracture or internal fixation failure. Hip pain symptoms were effectively relieved in most patients.@*CONCLUSION@#Less invasive intramedullary nail fixation combined with titanium cable cerclage can obtain good alignment and stability of fracture ends, which is an effective method for the treatment of subtrochanteric fractures.

Comparison of long Gamma 3 nail and proximal femur locking plate for the treatment of femoral subtrochanteric fractures / 中国骨伤

OBJECTIVE@#To compare clinical efficacy of long Gamma 3 nail and proximal femur locking plate (PFLP) in treating femoral subtrochanteric fractures.@*METHODS@#From January 2010 to January 2017, clinical data of 58 patients with subtrochanteric fractures followed more than 12 months were retrospective analyzed. Among them, 35 patients were treated with long Gamma 3 nail including 18 males and 17 females aged from 25 to 78 years old with an average of(66.5±23.5) years old;Causes of injury included fall on the ground in 18 cases, traffic accidents in 7 cases, and fall from height in 10 cases. The other 23 patients were treated with PFLP fixation including 8 males and 15 females aged from 31 to 81 years old with an average of (63.4±22.4) years old;Causes of injury included fall on the ground in 12 cases, traffic accidents in 6 cases, and fall from height in 5 cases. Operative time, blood loss (intraoperative and hidden blood loss), hospital stays, bone healing and complications were observed and compared. Harris hip score after 1-year following-up was used to evaluate postoperative clinical effect.@*RESULTS@#Fifty-one patients were followed up from 14 to 36 months with an average of 24.8 months, including 31 patients were treated with long Gamma 3 and 20 patients were treated with PFLP. Blood loss(intraoperative and hidden blood loss) in PFLP group was less than that of long Gamma 3 nail group(0.05). There was no significant differences in healing time of fractures between long Gamma 3 nail group (17.2±2.4) weeks and PFLP group (18.1±2.6) weeks(<0.05). At 1-year following-up, there was no significant differences in Harris hip score between long Gamma 3 nail group(80.29±10.28) and PFLP group (76.49±12.28)(<0.05). No complications such as pulmonary embolism and nonunion occurred. Two patients were treated with fitler whose occurred deep vein thrombosis. Postoperative pulmonary infection curred in 4 cases and was cured by anti-infection therapy.@*CONCLUSIONS@#Both of long Gamma 3 nail and PFLP in treating patients with femoral subtrochanteric fractures can receive good clinical effects, long Gamma 3 nail is not suitable for the patients of the narrow medullary cavity and prominent anterior arch. PFLP is eccentric fixation, so early weight-bearing was not stress.

Intertrochanteric and subtrochanteric fractures outcome on surgery

Background: Intertrochanteric and subtrochanteric fractures are leading cause of hospital admissions in elderly people. Aim: This study was done to analyze the surgical management of proximal third fractures of femur using Proximal Femoral Nail fixation. Materials and methods: 20 cases there were 15 male and 5 female patients of intertrochanteric and subtrochanteric fractures, which were treated with Proximal Femoral nail. Results: Mean age of 60.4 years. 50% of cases were admitted due to slip and fall and with slight predominance of right side. Out of 20 cases, 10 were trochanteric and 10 were subtrochanteric. In Trochanteric class 60% were Boyd and Griffin type 2, in Subtrochanteric class 40% were Seinsheimer type 3a and 20% were 2b. Mean duration of hospital stay is 19.33 days and mean time of full weight bearing is 12.6 weeks. Out of 20 cases 2 cases expired before first follow up and 1 case lost for follow up. Out of 17 remaining cases 9 were Trochanteric and 8 were Subtrochanteric. Good to excellent results are seen in 100% cases of trochanteric fractures and 87.5% cases of subtrochanteric fractures. Conclusion: We consider that PFN is an excellent implant for the treatment of proximal third fractures of femur.

Factors Affecting Time to Bony Union of Femoral Subtrochanteric Fractures Treated with Intramedullary Devices / 대한고관절학회지

PURPOSE: To evaluate the factors affecting the bone union time and the occurrence of nonunion after intramedullary nailing of subtrochanteric femoral fractures in adults. MATERIALS AND METHODS: We retrospectively reviewed data from 31 patients (22 men and 9 women) who had undergone femoral intramedullary nailing at least 1 year post-operatively and analyzed the bone union time, nonunion rates, and factors that affected the bone union time according to the fracture classification (AO and Fielding classifications), comminution of the medial cortex, reduction method, and additional cerclage wiring. RESULTS: The average union time was 26.4 weeks. There were no differences in the bone union time according to the fracture classification, reduction method, or additional cerclage wiring. Significant differences were found in the bone union time between the medial cortex comminution and non-comminution groups. A relatively strong positive correlation was detected between the degree of post-operative displacement and the bone union time. Nonunion occurred in three cases and there was no failure of implants. CONCLUSION: The bone union time was not affected by the reduction method nor additional cerclage wiring in intramedullary nailing of subtrochanteric femur fractures. Comminution of the medial cortex and the degree of the postoperative displacement of fractures contributed to the delayed time of union.

The Proximal Femoral Nail - A Minimal Invasive Treatment for the Stabilization of Pertrochanteric and Subtrochanteric Femoral Fractures.

This study reports the outcome in pertrochanteric and subtrochanteric femoral fractures in 25 patients treated by using PFN. Salvati and Wilson hip function scoring system and Kyle's criteria were used for follow up evaluation. At the end of 24 weeks follow up the Salvati and Wilson hip function was 32 (out of 40) in 88% of patients, the Kyle's criteria described the outcome as good or very good in 92% of patients and the level of function was similar to pre-injury level in 90% of patients. Distal locking difficulty was encountered in 3 cases. Difficulty in placement of neck screw was encountered in 4 cases. Secondary varus was noted in 3 cases and in 1 patient antirotational screw cut through was seen.However all fractures united well in all the patients.PFN was designed by AO/ASIF in 1996 for the treatment of peritrochanteric fractures.It combines the intrinsic advantages of the intramedullary nail and those of sliding screw is a valid and an important option in the treatment of pertrochanteric and subtrochanteric femoral fractures. It is a relatively easy procedure, a bio mechanically stable construct and a minimally invasive device; especially ideal in compromised elderly patients who are the majority population suffering from these type of fractures.With incorporation of single helical blade in place of two proximal screws in PFN, AO/ASIF has further enhanced the treatment modalities by devising PFNA (Proximal Femoral Nail Antirotation).

Deep Femoral Vessel Injury Following Subtrochanteric Hip Fracture: A Case Report

Arterial trauma associated with hip fracture treatment is still a rare complication. We present a case in which an arterial injury was discovered during closed reduction and intramedullary nail fixation of a subtrochanteric hip fracture. The preoperative thigh circumference was increased due to severe swelling, and the vascular injury was located substantially proximal to the fracture and the instrumentation area. An interventional angiogram revealed a damaged vessel originating from one of the minor proximal branches of the right deep femoral artery while filling a 2 cm-sized pseudoaneurysm. Embolization was performed without further complications.

Treatment of Comminuted Subtrochanteric Fractures of the Femur by High-Energy Trauma

PURPOSE: The purpose is to evaluate the effectiveness of open reduction and internal fixation in comminuted subtrochanteric fractures caused by high energy trauma at a non-osteoporotic young age. MATERIALS AND METHODS: Of all cases of subtrochanteric fractures caused by high energy trauma under 60 years old from February 2000 to February 2004, we analyzed 16 patients who had severe comminuted fractures (Seinsheimer classification type IV, V). The mean age is 43.5 (31~54) years old. Mean follow-up period was 22 (14~38) months. We tried to reduce anatomically as much as possible and fixed firmly using a compression hip screw in all cases. Additional procedures such as interfragmentary screw fixation, cerclage wiring or lateral stabilization plating were performed in 13 cases. Bone grafting was performed in 8 cases. We evaluated bony union rate, time to union, status of reduction, varus deformity and rate of implant failure using a simple X-ray. We also analyzed the clinical result using the Harris hip score including range of motion, pain and limping gait, so on. RESULTS: In all 16 cases, bony union was achieved and the mean time to union was 24 (20~32) weeks. There was no intra-operative complication. Postoperative complications such as loss of reduction, varus deformity, implant failure or infection did not occur. Clinically, the Harris hip score was 98.9 (97~100) points. CONCLUSION: Optimal open reduction and firm internal fixation with or without additional fixation was thought to be a recommendable method of treatment for comminuted subtrochanteric fractures of the femur caused by high energy trauma at a young age.